Saturday, 15 November 2025 08:35 pm
Naked Mole Rats
The risk of death increases exponentially with age.
So says the Gompertz-Makeham law, but that’s not always true,
For naked mole rats never reach a geriatric stage,
Unless they do much later than all other rodents do.
The oldest in captivity has died at 39.
A normal mammal of its size could scarcely live to six.
What’s more, the older females still can reproduce just fine.
How do they buck the pattern that biology predicts?
We’ve found that they are very good with DNA repair
And chaperones, the proteins that help other proteins fold.
A change to enzyme cGAS means its presence won’t impair
Genetic damage healing, so the rodents don’t grow old.
That said, there are some markers that result from methylation
To estimate their ages if we look at DNA.
Perhaps these markers point to not decline but preservation.
A sticky acid molecule keeps cancer cells at bay.
Moreover, naked mole rats can resist some types of pain
And live for 18 minutes never taking any breath.
Who knows how many benefits we humans stand to gain
From studying this species or how long we’ll stave off death?
So says the Gompertz-Makeham law, but that’s not always true,
For naked mole rats never reach a geriatric stage,
Unless they do much later than all other rodents do.
The oldest in captivity has died at 39.
A normal mammal of its size could scarcely live to six.
What’s more, the older females still can reproduce just fine.
How do they buck the pattern that biology predicts?
We’ve found that they are very good with DNA repair
And chaperones, the proteins that help other proteins fold.
A change to enzyme cGAS means its presence won’t impair
Genetic damage healing, so the rodents don’t grow old.
That said, there are some markers that result from methylation
To estimate their ages if we look at DNA.
Perhaps these markers point to not decline but preservation.
A sticky acid molecule keeps cancer cells at bay.
Moreover, naked mole rats can resist some types of pain
And live for 18 minutes never taking any breath.
Who knows how many benefits we humans stand to gain
From studying this species or how long we’ll stave off death?